Bodybuilding

The Best Weight-Loss Supplements of 2021

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When many people think of weight-loss supplements, they think of fat burners. And while fat burners can play a crucial role in leaning out, they’re not the only tool you need in your toolbox! Other supplements, ranging from CLA to protein to L-carnitine, can all help you break through the barriers and finally achieve lasting, sustainable weight loss.



Read our fat-burners guide to learn about the best fat burners of 2021. These are the best ”other” weight-loss supplements that are worth your money. Just remember: Every single one of them works best as part of a comprehensive nutritional and training plan built around losing weight.

How We Chose the Best Weight-Loss Supplements

Weight loss is complicated, and there are many factors that go into getting the results you want. But with over 20 years in the game, we know weight-loss supplements because we’ve taken them. Our team of fitness experts and our discerning online reviewers informed this list by these standards:

  • Ingredients: We looked for products with quality ingredients and dosages backed up by research, not just trendy buzzwords. No inadequate ”dustings” of key ingredients here!
  • Customer Feedback: To know what works, we listen to the people who use them! Many of our customers are physique competitors and bodybuilders, so they’re extra picky about what supplements they use.
  • Value: Our community knows its prices, so we only included products that deliver high quality at a good value.

The Best Supplements for Weight Loss

Best Fat Burner: EVL LeanMode 

EVL LeanMode
  • Key Ingredients: L-carnitine, Garcinia cambogia, green tea, green coffee, CLA
  • Rating: 4.5 out of 5 

EVL LeanMode is an all-around solution that handles weight loss from several fronts, including metabolism, appetite, and fat-burning. It tackles it from a physical and mental point of view with hydroxycitric acid (HCA) to help prevent binge eating. You can take it twice a day before meals for optimal results.

Flavors: Unflavored, Fruit Punch

Best CLA: Signature CLA Weight Loss Supplement

Signature CLA
  • Key ingredients: Safflower Oil, Conjugated Linoleic Acid
  • Caffeine per serving: 0 mg
  • Rating: 4 out of 5

Signature CLA is a stimulant-free healthy fat-loss supplement used to support the body’s metabolism. Signature CLA includes Conjugated Linoleic Acid is an omega-6 fatty acid, which is a great source of fatty-acid to fuel your everyday nutrition

Best Ketogenic: Beverly International 7-Keto MuscLean

Beverly International
  • Key ingredients: 7-Keto DHEA, green tea, guarana
  • Caffeine per serving: 110 mg
  • Rating: 4.4 out of 5

While Lean Out helps your body transport fat to tissues where it can be burned, 7-Keto MuscLean helps to stimulate your metabolism to burn fat more quickly. Clinically based: Its flagship ingredient, 7-Keto®, has been tested in numerous clinical trials and been granted 5 U.S. patents for its effects on weight loss.

Best Appetite Support: Jym SS8 Super Shredded 8

JYM SS8
  • Key Ingredients: Caffeine, capsicum extract, green tea extract, chromium, yohimbine
  • Rating: 4.3 out of 5 

Jym SS8 Super Shredded 8 kicks it into overdrive with this upgraded formula for optimal weight loss. It uses several ingredients to help burn fat while adding caffeine for increased exercise endurance. The dosing is once a day with four capsules, with or without food. It’s best taken in the morning if you are sensitive to caffeine. The product is also vegetarian-friendly.



Best L-Carnitine: RSP Liquid L-Carnitine 

RSP Nutrition Liquid l-Carnitine
  • Key Ingredients: L-carnitine
  • Rating:  4.8 out of 5

L-carnitine is a stimulant-free supplement that supports the body’s natural fat-burning processes. Some people find it also helps control fatigue and even muscle soreness during intense training, so they can put more into their fat-torching workouts. The timing of when you take it doesn’t make a huge difference, but experts say it’s more effective when taken with carbs—preferably your highest-carb meal of the day.*

RSP’s liquid L-carnitine comes in two highly-rated fruit flavors, which you can either swig as-is or add to a protein shake or smoothie.

Flavors: Peach Mango (9.8), Berry (9.7)

Best All-In-One: Animal Cuts Powder

Animal Cuts
  • Key ingredients: Melatonin, L-theanine, GABA, 5-HTP
  • Caffeine per serving: 0 mg
  • Rating: 9.9 out of 10

Convenient all-in-one fat burner to promote metabolic rate increases, fat burning, water shredding, appetite control and focus factores.

Best Protein Bar: BSN Protein Crisp Bar

BSN Protein Crisp
  • Key Ingredients: Whey protein isolate, whey protein concentrate, milk protein concentrate 
  • Rating: 4.7 out of 5 

One look at the flavors of the BSN Protein Crisp Bar might make you think it wouldn’t support weight loss. However, each one is only 240 calories and supplies 20 g of protein with only 3 g of sugar. Three sources provide the protein content. The bars are excellent sources of potassium and calcium, too. They are also gluten-free.

Flavors: S’Mores, Birthday Cake Remix, Mint Chocolate Chip, Chocolate Crunch, Salted Toffee Pretzel, Vanilla Marshmallow

Best Low-Carb Protein Powder for Weight Loss: Isopure Zero Carb WPI

Isopure Zero Carb WPI
  • Key ingredients: Whey protein isolate
  • Rating: 8.6 out of 10

Many popular weight-loss diets cap the number of carbs you can eat. This is where Isopure Zero Carb WPI fits beautifully into any diet, delivering, as advertised, zero carbs. Its stripped-down formula is easy to digest, so you can combine it with heavy-hitter ingredients like peanut butter and avocados in a low-carb shake that fills you up without weighing you down.



Flavors: Cookies & Cream (7.8), Creamy Vanilla (7.7), Strawberries & Cream (7.6)

Best Meal Replacement Protein: Kaged Clean Meal

Kaged Clean Meal
  • Key Ingredients: Whey protein isolate 
  • Rating: n/a 

Kaged Clean Meal is an excellent choice for a meal replacement that ticks off all the boxes you want to see in this type of product. One serving provides 28 g of protein, 6.5 g BCAAs, and 21 vitamins and minerals. It is a nutritional powerhouse! Its carb and fiber content comes from Swedish oats and quinoa. The two combined will leave you feeling sated with excellent muscle-building support.

Flavors: Snickerdoodle, Vanilla Cake

Best Healthy Fat: Bodybuilding.com Signature CLA Weight-Loss Supplement

Signature CLA
  • Key Ingredients: Safflower oil  
  • Rating: 4.0 out of 5 

Signature CLA Weight Loss Supplement is a stimulant-free product that ramps up fat loss with omega-6 fatty acids. Safflower oil provides a polyunsaturated fat source with only 10 calories and 1 g fat per serving. You can take up to four capsules a day with this easily digestible supplement. It is also gluten-free with 800 mg CLA.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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